In 2016, she filmed with Caan's father James Caan and Jon Voight in a TV-movie titled J. In 2014, Griffith reunited onscreen with Banderas in the science fiction film Automata directed by Gabe Ibanez. She then had roles in several other films, including Day Out of Days (2015) directed by Zoe Cassavetes, and opposite Al Pacino and Evan Peters in Where the White Man Runs Away (2016), a biopic about journalist Jay Bahadur.
Griffith supports the efforts of Children's Hospital Los Angeles helping to lead Walk for Kids, a community 5k, to raise funds as part of the hospital's community awareness efforts in support of the opening of a new state-of-the-art pediatric inpatient facility.
It led to her first starring role in Jonathan Demme's Something Wild (1986), which became a cult favorite.
During the filming she was attacked by a lion and had 50 stitches to her face; it was feared she would lose an eye but in the end the wound was not disfiguring.
She then appeared in the made-for-television movie She's in the Army Now (1981) with Jamie Lee Curtis and Steven Bauer, whom she married shortly after the film premiered.
They had a son, Alexander Griffith Bauer, born on August 22, 1985.
The couple divorced in 1989 after a long separation.
Griffith's subsequent performance in Something Wild (1986) garnered critical acclaim before she was cast in 1988's Working Girl, which earned her a nomination for the Academy Award for Best Actress and won her a Golden Globe.
The 1990s saw Griffith in a series of roles which received varying critical reception: she received Golden Globe nominations for her performances in Buffalo Girls (1995), and as Marion Davies in RKO 281 (1999), while also earning a Golden Raspberry Award for Worst Actress for her performances in Shining Through (1992), as well as receiving nominations for Crazy in Alabama (1999) and John Waters' cult film Cecil B. Other roles include in John Schlesinger's Pacific Heights (1990), Milk Money (1994), the neo-noir film Mulholland Falls (1996), as Charlotte Haze in Adrian Lyne's Lolita (1997), and Another Day in Paradise (1998).
She also participated in the hospital's 2012 Noche de Niños gala as a presenter of a Courage to Care Award.
On September 8, 1981, Griffith married Steven Bauer, her co-star from the TV film She's in the Army Now.
Griffith's well-known drug and alcohol addictions stalled her career, but she made a comeback at age 26 with her role as a porn actress in the Brian De Palma thriller Body Double (1984).