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Speech development is especially delayed in children with cri du chat syndrome.

Affected children usually understand speech better than they can communicate.

In French, Cri du chat translates into “cry of the cat”.

The symptoms of cri du chat syndrome vary from case to case.

In one study, only 50% of children with cri du chat syndrome were able to feed themselves with a spoon by 3.5 years of age.

A variety of additional findings may occur in association with cri du chat syndrome.

The characteristic high-pitched, shrill cry associated with cri du chat syndrome is present during the first few weeks of life.

The cry, which resembles the mewing of a cat, becomes less pronounced as affected infants grow older.

NORD gratefully acknowledges Scott Pentiuk MD, Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, and Adam Mezoff, MD, Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, for assistance in the preparation of this report.

Summary Cri du chat syndrome (Cd CS or 5p-) is a rare genetic disorder in which a variable portion of the short arm of chromosome 5 is missing or deleted (monosomic).

Most cases are thought arise from spontaneous (de novo) genetic errors very early in embryonic development.

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