Now with Carson Palmer (arm) out for eight weeks, the Cardinals will try to lean on Peterson on the ground.
Desperate for a workhorse with David Johnson (wrist) on the shelf, Arizona handed the reigns to Peterson, who came through with 134 yards and two touchdowns on a season-high 26 carries in his Cardinals debut.
Sunday marked Peterson's first 100-yard rushing game since Week 16 of 2015.
Peterson will attempt to bang between the tackles behind Arizona's undermanned offensive line, Andre Ellington will catch passes and Kerwynn Williams will handle 2-3 weekly touches.
Despite the poor setup — the Cardinals' line hasn't blocked a soul this season — Peterson is a legitimate RB3 for Week 6.
The 32-year-old said he still has plenty left in the tank and on Sunday, he proved to be a man of his word.
If Peterson was dropped in your league, make sure to scoop him up ahead of next week's game against the Rams.
But with Drew Stanton under center, defenses are going to jam up the running lanes.
He added they could get Peterson involved in the passing game now that he has more of the playbook down, something they may need with Andre Ellington unlikely to play against the Rams.
The Cardinals need to find a way to jump-start the running game, and Peterson is a good fit in their power scheme.